Development of New Methodology for Bond Activation by Transition Metal Complexes andTheir Application toward Functional Molecule Synthesis

Time March 22, 2010, 09 00 AM

Location Academic Hall on Foor 1 of SKLC

Yasushi Nishihara

Division of Chemistry and Biochemistry, Graduate School of Naural Science and Technology,Okayama University, 3-1-1 Tsushimanaka, Kita-ku, Okayama 700-8530, Japan

Introduction:

Education:

B Sc: 1992, Faculty of Science, Hiroshima University

M Sc: 1994, Graduate School of Science, Hiroshima University

Ph D: 1997, The Graduate University for Advanced Studies

Professional Experience:

1994-2004 Assistant Professor: Chemical Resources Laboratory,Tokyo Institute of Technology

2004-2010 Associate Professor: Department of Chemistry, Okayama University

2010.4 Professor: Department of Chemistry, Okayama University

2009.5-7 Visiting Associate Professor: National Taiwan University

Awards and Fellowship:

JSPS Fellowship (1996), Nippon Shokubai Award in Synthetic Organic Chemistry, Japan(2002), Chemical Society of Japan Presentation Award 2008 for Industries (2008), IncentiveAward in Synthetic Organic Chemistry, Japan (2009), Incentive Culture Award in Okayama

Prefecture, Japan (2010)

Abstract

In this lecture, the results of studies on new methodology for bond activation by using transition metal complexesare described, in order to realize the expeditious and selective synthesis of organic compounds. Carbon-carbonbond formation reactions, accompanying with cleavage of unactivated bonds such as carbon-carbon, carbon-boron,and carbon-silicon bonds, are reported.

This lecture involves, for examples, cross-coupling reaction ofalkynylsilanes activated by a copper salt via the C-Si bond, regio- and steleoselective synthesis multi-substitutedolefins mediated a zirconocene complex via the C-B bond activation, and the new synthetic methodology tointroduce both cyano and ester groups (cyanoesterification) via the C-C bond activation.

Each reaction can beapplicable to synthesis of functional molecules such as liquid crystalline compounds, an anti-cancer agent, andopto-electronic materials.

Contact: Yonggui Zhou 9220