| Flax Seed Extract Designed to Help the Skin Optimize Lipidic Homeostasis Even After Detergent Damages |
| Wayne - NJ - November 4, 2010 Helping consumers achieve younger, healthier-looking skin begins with effective protection against environmental factors. To help optimize the skin s barrier function, ISP has introduced Lipigenine , a novel ingredient that may help boost skin lipid synthesis in the stratum corneum for optimized lipidic homeostasis and better protection of the skin. Lipid Synthesis and Homeostasis Recovery The stratum corneum is composed of corneocytes and intercellular lipids, which contain ceramides (50%), cholesterol (25%), fatty acids (15%) and cholesterol sulfate (2-5%). In the granular layer, smooth endoplasmic reticulum and the Golgi apparatus of keratinocytes contribute to initial lipid synthesis. The storage, transportation and secretion of these lipids into the stratum corneum are supported by lamellar bodies, which are derived from the Golgi apparatus. The skin regularly produces these bodies and lipids to maintain skin barrier integrity, but this ability diminishes with age, resulting in an imbalance in homeostasis and, ultimately, dry skin. Lipigenine, a flax seed extract, was designed to help the skin optimize lipidic homeostasis by boosting the synthesis of stratum corneum intercellular lipids (e.g., ceramides, cholesterol, fatty acids). Ex-vivo studies show that Lipigenine may also help favor lipid transportation and secretion by promoting lamellar bodies (secretory vesicles that ensure lipid storage, transportation and secretion). Developed around HMG-CoA reductase, a key enzyme of skin cholesterol synthesis, Lipigenine may help target cholesterol synthesis, as shown by a boost in HMG-CoA reductase enzyme expression (ex-vivo). Under stress conditions (e.g., exposure to detergent), Lipigenine may help the skin to recover to a state of optimal lipidic homeostasis, providing visible results on stratum corneum protection and on skin beautification (e.g., radiance, hydration, tonicity, elasticity), as shown in-vivo. Consumer Benefits Lipigenine was designed to help the skin optimize lipidic homeostasis and support the barrier function. In-vivo testing, as well as expert evaluation, demonstrated the ingredient s ability to help skin boost lipid synthesis, help restore lipid content in the stratum corneum following detergent damage and overall beautify the skin. This protective property makes Lipigenine ideal for skin care products positioned for consumers with dry and sensitive skin and in products to counter the drying effects of daily exposure to detergents and soaps. Lipidic homeostasis is crucial to helping consumers maintain well-hydrated and well-protected skin. Because Lipigenine was designed to help skin achieve this balance even after detergent damage, ISP is helping consumers achieve younger-looking, more supple skin, said Joel Mantelin, Global Marketing Director, Skin Care. Once again, our advanced research skin care laboratory in Sophia Antipolis, France has come up with an innovative skin care technology that has the potential to protect and maintain the youthful appearance of skin. Consumers all around the world will be the winners from their efforts. Lipigenine is now available globally from ISP. For more information, contact an ISP representative today. |
